Renin anticorps (C-Term)

N° du produit ABIN7602836

Cet anticorps anti-Renin est un anticorps Lapin Polyclonal détectant Renin dans IHC. Adapté pour Humain.

Aperçu rapide pour Renin anticorps (C-Term) (ABIN7602836)

Antigène: Renin (REN)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Renin est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-Renin anticorps

Épitope: C-Term

Fonction: Anti-REN/Renin Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-REN/Renin Antibody Picoband® (ABIN7602836). Tested in IHC applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human REN/Renin, which shares 95% and 95% amino acid (aa) sequence identity with mouse and rat REN/Renin, respectively.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
1. Abel, K. J., Gross, K. W. Close physical linkage of the murine Ren-1 and Ren-2 loci. Nucleic Acids Res. 16: 2111-2126, 1988. 2. Caron, K. M. I., James, L. R., Kim, H.-S., Knowles, J., Uhlir, R., Mao, L., Hagaman, J. R., Cascio, W., Rockman, H., Smithies, O. Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene. Proc. Nat. Acad. Sci. 101: 3106-3111, 2004. 3. Chirgwin, J. M., Schaefer, I. M., Diaz, J. A., Lalley, P. A. Mouse kidney renin gene is on chromosome one. Somat. Cell Molec. Genet. 10: 633-637, 1984.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur Renin

Antigène: Renin (REN)

Autre désignation: REN

Sujet:

Synonyms: p-selectin glycoprotein ligand, Selplg, Psgl1

Tissue Specificity: Highly expressed in blood, bone marrow, brain, adipose tissue, spleen, and thymus. Also expressed in heart, kidney, liver, muscle, ovary, and stomach.

Background: This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis.

Poids moléculaire: 53-60 kDa

ID gène: 5972

UniProt: P00797

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour